{ "_id": "6a33cf953efcd9bda43b39f7", "Package": "AccelStab", "Title": "Accelerated Stability Kinetic Modelling", "Version": "2.3.2", "Authors@R": "c(person(\"Bernard G\", \"Franq\", email = \"accelstab@gmail.com\", role = c(\"aut\", \"cph\")),\nperson(\"Ben\", \"Wells\", email = \"wellsbenjy@gmail.com\", role = \"ctb\"),\nperson(\"Alex\", \"Ball\", email = \"alex_keith_ball@hotmail.com\", role = c(\"cre\")),\nperson(\"Daniel\", \"Williams\", email = \"daniel@bayezian.com\", role = \"ctb\"))", "Description": "Estimate the Šesták–Berggren kinetic model (degradation\nmodel) from experimental data. A closed-form (analytic)\nsolution to the degradation model is implemented as a\nnon-linear fit, allowing for the extrapolation of the\ndegradation of a drug product - both in time and temperature.\nParametric bootstrap, with kinetic parameters drawn from the\nmultivariate t-distribution, and analytical formulae (the delta\nmethod) are available options to calculate the confidence and\nprediction intervals. The results (modelling, extrapolations\nand statistical intervals) can be visualised with multiple\nplots. The examples illustrate the accelerated stability\nmodelling in drugs and vaccines development.", "License": "AGPL (>= 3)", "Encoding": "UTF-8", "RoxygenNote": "7.3.2", "VignetteBuilder": "knitr", "Config/testthat/edition": "3", "Roxygen": "list(markdown = TRUE)", "LazyData": "true", "Language": "en-GB", "URL": "https://github.com/AccelStab/AccelStab", "BugReports": "https://github.com/AccelStab/AccelStab/issues", "Repository": "https://accelstab.r-universe.dev", "Date/Publication": "2025-08-21 12:48:14 UTC", "RemoteUrl": "https://github.com/accelstab/accelstab", "RemoteRef": "HEAD", "RemoteSha": "64381dc84f8cb154410f077c6c879b8d9ff8b15c", "NeedsCompilation": "no", "Packaged": { "Date": "2026-06-18 10:55:23 UTC", "User": "root" }, "Author": "Bernard G Franq [aut, cph],\nBen Wells [ctb],\nAlex Ball [cre],\nDaniel Williams [ctb]", "Maintainer": "Alex Ball ", "MD5sum": "3bcdf94ace3c0771b1d058dedd3348b8", "_user": "accelstab", "_type": "src", "_file": "AccelStab_2.3.2.tar.gz", "_fileid": "9c4f3e5d1c14d4d3c8707094629c69cacb3f3eefd7bb505c1988b786a6bd17bf", "_filesize": 4398621, "_sha256": "9c4f3e5d1c14d4d3c8707094629c69cacb3f3eefd7bb505c1988b786a6bd17bf", "_created": "2026-06-18T10:55:23.000Z", "_published": "2026-06-18T10:59:33.104Z", "_distro": "noble", "_jobs": [ { "job": 82113366641, "time": 134, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "7721362919" }, { "job": 82113366626, "time": 153, "config": "linux-release-x86_64", "r": "4.6.0", "check": "OK", "artifact": "7721369280" }, { "job": 82113366642, "time": 209, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "7721376036" }, { "job": 82113366634, "time": 167, "config": "macos-release-arm64", "r": "4.6.0", "check": "OK", "artifact": "7721364806" }, { "job": 82112707931, "time": 227, "config": "source", "r": "4.6.0", "check": "OK", "artifact": "7721317467" }, { "job": 82113366627, "time": 99, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "7721351278" }, { "job": 82113366650, "time": 131, "config": "windows-devel", "r": "4.7.0", "check": "OK", "artifact": "7721361711" }, { "job": 82113366633, "time": 101, "config": "windows-oldrel", "r": "4.5.3", "check": "OK", "artifact": "7721351483" }, { "job": 82113366630, "time": 123, "config": "windows-release", "r": "4.6.0", "check": "OK", "artifact": "7721359757" } ], "_buildurl": "https://github.com/r-universe/accelstab/actions/runs/27754425430", "_status": "success", "_host": "GitHub-Actions", "_upstream": "https://github.com/accelstab/accelstab", "_commit": { "id": "64381dc84f8cb154410f077c6c879b8d9ff8b15c", "author": "AccelStab <151023065+AccelStab@users.noreply.github.com>", "committer": "GitHub ", "message": "Merge pull request #65 from AccelStab/dev\n\ncran check issue fixed", "time": 1755780494 }, "_maintainer": { "name": "Alex Ball", "email": "alex_keith_ball@hotmail.com", "login": "bobidan97", "description": "", "uuid": 72048414 }, "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 4.1.0", "role": "Depends" }, { "package": "dplyr", "role": "Imports" }, { "package": "ggplot2", "role": "Imports" }, { "package": "minpack.lm", "role": "Imports" }, { "package": "stats", "role": "Imports" }, { "package": "scales", "role": "Imports" }, { "package": "testthat", "version": ">= 3.0.0", "role": "Suggests" }, { "package": "knitr", "role": "Suggests" }, { "package": "rmarkdown", "role": "Suggests" }, { "package": "lifecycle", "role": "Suggests" } ], "_owner": "accelstab", "_selfowned": true, "_usedby": 0, "_updates": [ { "week": "2025-25", "n": 1 }, { "week": "2025-27", "n": 1 }, { "week": "2025-34", "n": 1 } ], "_tags": [ { "name": "v2.3.1", "date": "2025-06-20" } ], "_topics": [ "arrhenius", "kinetics", "modelling", "non-linear-model", "pharmaceuticals", "pharmacokinetics", "sestak-berggren", "stability", "statistics", "temperature", "temperature-excursion", "vaccine" ], "_stars": 4, "_contributors": [ { "user": "danielpwilliams137", "count": 57, "uuid": 195778811 }, { "user": "benwells0", "count": 46, "uuid": 112945721 }, { "user": "bobidan97", "count": 39, "uuid": 72048414 }, { "user": "accelstab", "count": 16, "uuid": 151023065 } ], "_userbio": { "uuid": 151023065, "type": "user", "name": "AccelStab", "followers": 3 }, "_downloads": { "count": 573, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/AccelStab" }, "_devurl": "https://github.com/accelstab/accelstab", "_searchresults": 12, "_rbuild": "4.6.0", "_assets": [ "extra/AccelStab.html", "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/NEWS.html", "extra/NEWS.txt", "extra/readme.html", "extra/readme.md", "manual.pdf" ], "_homeurl": "https://github.com/accelstab/accelstab", "_realowner": "accelstab", "_cranurl": true, "_releases": [ { "version": "1.0.0", "date": "2023-12-10" }, { "version": "2.0.0", "date": "2024-02-14" }, { "version": "2.0.1", "date": "2024-03-26" }, { "version": "2.0.2", "date": "2024-10-21" }, { "version": "2.1.0", "date": "2025-01-08" }, { "version": "2.1.1", "date": "2025-01-20" }, { "version": "2.2.0", "date": "2025-05-19" }, { "version": "2.2.1", "date": "2025-05-27" }, { "version": "2.3.1", "date": "2025-07-01" }, { "version": "2.3.2", "date": "2025-08-21" } ], "_exports": [ "excursion", "step1_down", "step1_down_basic", "step1_down_rmse", "step1_plot_CI", "step1_plot_desc", "step1_plot_diagnostic", "step1_plot_PI", "step1_plot_pred", "step1_plot_T", "step1_sample_mvt" ], "_datasets": [ { "name": "antigenicity", "title": "Antigenicity Accelerated Stability Data", "object": "antigenicity", "class": [ "data.frame" ], "fields": [ "time", "Celsius", "K", "conc", "N.days", "validA" ], "rows": 56, "table": true, "tojson": true }, { "name": "potency", "title": "Potency Accelerated Stability Data", "object": "potency", "class": [ "data.frame" ], "fields": [ "Time", "Potency", "Celsius" ], "rows": 78, "table": true, "tojson": true } ], "_help": [ { "page": "antigenicity", "title": "Antigenicity Accelerated Stability Data", "topics": [ "antigenicity" ] }, { "page": "excursion", "title": "Temperature Excursion", "topics": [ "excursion" ] }, { "page": "potency", "title": "Potency Accelerated Stability Data", "topics": [ "potency" ] }, { "page": "step1_down", "title": "Step1 Down Model", "topics": [ "step1_down" ] }, { "page": "step1_down_basic", "title": "Basic version Step1 Down Model", "topics": [ "step1_down_basic" ] }, { "page": "step1_down_rmse", "title": "Step1 Down Model Root Mean Square Error Calculation", "topics": [ "step1_down_rmse" ] }, { "page": "step1_plot_CI", "title": "Plot Confidence Intervals", "topics": [ "step1_plot_CI" ] }, { "page": "step1_plot_desc", "title": "Plot Stability Data", "topics": [ "step1_plot_desc" ] }, { "page": "step1_plot_diagnostic", "title": "Create Diagnostic Plots", "topics": [ "step1_plot_diagnostic" ] }, { "page": "step1_plot_PI", "title": "Plot Prediction Intervals", "topics": [ "step1_plot_PI" ] }, { "page": "step1_plot_pred", "title": "Plot Model Predictions", "topics": [ "step1_plot_pred" ] }, { "page": "step1_plot_T", "title": "Focus on Temperature", "topics": [ "step1_plot_T" ] }, { "page": "step1_sample_mvt", "title": "Sample the Multivariate t Distribution", "topics": [ "step1_sample_mvt" ] } ], "_readme": "https://github.com/accelstab/accelstab/raw/HEAD/README.md", "_rundeps": [ "cli", "cpp11", "dplyr", "farver", "generics", "ggplot2", "glue", "gtable", "isoband", "labeling", "lifecycle", "magrittr", "minpack.lm", "pillar", "pkgconfig", "R6", "RColorBrewer", "rlang", "S7", "scales", "tibble", "tidyselect", "utf8", "vctrs", "viridisLite", "withr" ], "_vignettes": [ { "source": "AccelStab.Rmd", "filename": "AccelStab.html", "title": "Accelerated Stability Analysis using AccelStab in R", "author": "Bernard G Francq, Ben Wells, Daniel Williams, Alex Ball", "engine": "knitr::rmarkdown", "headings": [ "Introduction", "The Sestak-Berggren model", "Antigenicity", "Visualisation", "Model Fit", "Predictions", "Statistical Intervals and Visualisation", "Temperature Excursion", "Customised calculations from sampling in the multi-t", "Zero order kinetic: Potency", "Starting Values", "Predictions and Statistical Intervals", "Inverse Predictions" ], "created": "2025-05-16 16:19:42", "modified": "2025-08-21 12:48:14", "commits": 3 } ], "_score": 5.334453751150932, "_indexed": true, "_nocasepkg": "accelstab", "_universes": [ "accelstab", "bobidan97" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "2.3.2", "date": "2026-06-18T10:57:13.000Z", "distro": "noble", "commit": "64381dc84f8cb154410f077c6c879b8d9ff8b15c", "fileid": "239ece6ba809d5e35ff8b06091ce07b3acf2c048dc810887242bdc11dc556925", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/accelstab/actions/runs/27754425430" }, { "r": "4.6.0", "os": "linux", "version": "2.3.2", "date": "2026-06-18T10:57:32.000Z", "distro": "noble", "commit": "64381dc84f8cb154410f077c6c879b8d9ff8b15c", "fileid": "8c77085fcaf6fe4311360b46850ac5251397de77f852a9d545d6ccb4330f3237", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/accelstab/actions/runs/27754425430" }, { "r": "4.5.3", "os": "mac", "version": "2.3.2", "date": "2026-06-18T10:58:00.000Z", "commit": "64381dc84f8cb154410f077c6c879b8d9ff8b15c", "fileid": "bf95a2af05e482212ebc845e9eea7ace28b3671c0729e5b40492c619faa6a7e0", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/accelstab/actions/runs/27754425430" }, { "r": "4.6.0", "os": "mac", "version": "2.3.2", "date": "2026-06-18T10:57:28.000Z", "commit": "64381dc84f8cb154410f077c6c879b8d9ff8b15c", "fileid": "08b76489bd28562fd6be254b8da43bc05dd04ab897e0724ed81d07812473cb9b", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/accelstab/actions/runs/27754425430" }, { "r": "4.6.0", "os": "wasm", "version": "2.3.2", "date": "2026-06-18T10:57:22.000Z", "commit": "64381dc84f8cb154410f077c6c879b8d9ff8b15c", "fileid": "db4f7786d46777aaaae778f3799e3e9f66d3806fb1820ef0438459235acd2118", "status": "success", "buildurl": "https://github.com/r-universe/accelstab/actions/runs/27754425430" }, { "r": "4.7.0", "os": "win", "version": "2.3.2", "date": "2026-06-18T10:56:49.000Z", "commit": "64381dc84f8cb154410f077c6c879b8d9ff8b15c", "fileid": "52944591ab07c8afc71cb9ccf8f6cc3c7bf4ce9b9f228dbb7371c325894d8884", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/accelstab/actions/runs/27754425430" }, { "r": "4.5.3", "os": "win", "version": "2.3.2", "date": "2026-06-18T10:56:31.000Z", "commit": "64381dc84f8cb154410f077c6c879b8d9ff8b15c", "fileid": "83ad4f77fa13134e15220e740b3e2d77cae8aadaa82ea068e0fd069a23e7a24c", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/accelstab/actions/runs/27754425430" }, { "r": "4.6.0", "os": "win", "version": "2.3.2", "date": "2026-06-18T10:56:41.000Z", "commit": "64381dc84f8cb154410f077c6c879b8d9ff8b15c", "fileid": "07e5c1b567992d495be5162ad960e7f5b0198197c8c80267747753d3cb92c1b6", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/accelstab/actions/runs/27754425430" } ] }