Package: AccelStab 2.0.1

Ben Wells

AccelStab: Accelerated Stability Kinetic Modelling

Estimate the Šesták–Berggren kinetic model (degradation model) from experimental data. A A closed-form (analytic) solution to the degradation model is implemented as a non-linear fit, allowing for the extrapolation of the degradation of a drug product - both in time and temperature. Parametric bootstrap, with kinetic parameters drawn from the multivariate t-distribution, and analytical formulae (the delta method) are available options to calculate the confidence and prediction intervals. The results (modelling, extrapolations and statistical intervals) can be visualised with multiple plots. The examples illustrate the accelerated stability modelling in drugs and vaccines development.

Authors:Bernard G Franq [aut, cph], Ben Wells [cre], Alex Ball [ctb]

AccelStab_2.0.1.tar.gz
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AccelStab.pdf |AccelStab.html
AccelStab/json (API)
NEWS

# Install 'AccelStab' in R:
install.packages('AccelStab', repos = c('https://accelstab.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/accelstab/accelstab/issues

Datasets:
  • antigenicity - Antigenicity Accelerated Stability Data
  • potency - Potency Accelerated Stability Data

On CRAN:

Conda:

arrheniuskineticsmodellingnon-linear-modelpharmaceuticalspharmacokineticssestak-berggrenstabilitystatisticstemperaturetemperature-excursionvaccine

3.48 score 1 stars 2 scripts 397 downloads 10 exports 33 dependencies

Last updated 5 months agofrom:a1448a88ff. Checks:9 OK. Indexed: yes.

TargetResultLatest binary
Doc / VignettesOKMar 15 2025
R-4.5-winOKMar 15 2025
R-4.5-macOKMar 15 2025
R-4.5-linuxOKMar 15 2025
R-4.4-winOKMar 15 2025
R-4.4-macOKMar 15 2025
R-4.4-linuxOKMar 15 2025
R-4.3-winOKMar 15 2025
R-4.3-macOKMar 15 2025

Exports:excursionstep1_downstep1_down_rmsestep1_plot_CIstep1_plot_descstep1_plot_diagnosticstep1_plot_PIstep1_plot_predstep1_plot_Tstep1_sample_mvt

Dependencies:clicolorspacedplyrfansifarvergenericsggplot2gluegtableisobandlabelinglatticelifecyclemagrittrMASSMatrixmgcvminpack.lmmunsellmvtnormnlmepillarpkgconfigR6RColorBrewerrlangscalestibbletidyselectutf8vctrsviridisLitewithr